Grant: Research Tools and Instruments - Category 1 (<$150,000)
Simon Fraser University
$149,982.00
X-ray microsource upgrade for accessing very small and/or organic single crystal structures
EF 2011-12
Résumé
Single-crystal X-ray diffraction, which literally provides a ""ball-and-stick"" picture of the solid-state structure of molecules, is perhaps the most critical characterization tool for inorganic chemists and is also very valuable for organic chemists, particularly for confirming atomic connectivity and relative (or absolute) stereochemistry. Although the SFU Chemistry Department has a modern single-crystal X-ray diffractometer, it is only equipped with a molybdenum-based X-ray source, which is not appropriate for making measurements on small and/or organic crystals. Thus, this proposal seeks funding for a critical upgrade to SFU's single-crystal X-ray diffractometer: the addition of a high-intensity copper-based microfocus X-ray source. This upgrade will greatly impact the research programs of most organic and inorganic chem. researchers at SFU by opening the door to obtaining high-quality structural data from small, weakly diffracting crystals and organic crystals.
This upgrade will support a wide range of research programs in SFU's chemistry department, including metal-coordination polymers for materials applications such as toxic gas sensors (Leznoff), organic nanomaterials for molecule-based circuit boards, photoactive therapeutics and drug-delivery vehicles (Branda), synthesis of new carbohydrate-based drugs (Bennet, Pinto) and of other natural products for human disease treatment (Britton), anti-cancer prodrugs (Walsby) and bimetallic oxidation catalysts for a range of molecular transformations (Storr). Each of these research areas critically require X-ray structure determinations from small, weakly diffracting crystals and/or organic crystals, which will become possible with the requested upgrade.
A substantial portion of SFU's Chemistry Dept. researchers will be impacted by this upgrade, and will be able to receive valuable hands-on training in determining molecular structures using single-crystal X-ray diffraction, as well as the safe use of X-ray infrastructure.
Programme
Research Tools and Instruments - Category 1 (<$150,000)
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
422060-2012
Name nom
Leznoff, Daniel
Department département
Chemistry
Organization id
5
Institution établissement
Simon Fraser University
Province en
British Columbia
Province fr
Colombie-Britannique
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2011
Competition year année de concours
2012
Award amount
149982
Program id
EQPEQ
Program nane en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
1504
Committee name en
Chemistry
Committee name fr
Chimie
Area of application code
1211
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Medical and health sciences
Area of application fr
Sciences médicales et de la santé
Research subject code
3407
Research subject group en
Physical chemistry
Research subject group fr
Chimie physique
Research subject en
Crystallography -- physical chemistry
Research subject fr
Chimie physique -- cristallographie
Partie
1
Nb partie
1
Application title
X-ray microsource upgrade for accessing very small and/or organic single crystal structures
Keyword
NSERC
Application summary
Single-crystal X-ray diffraction, which literally provides a ""ball-and-stick"" picture of the solid-state structure of molecules, is perhaps the most critical characterization tool for inorganic chemists and is also very valuable for organic chemists, particularly for confirming atomic connectivity and relative (or absolute) stereochemistry. Although the SFU Chemistry Department has a modern single-crystal X-ray diffractometer, it is only equipped with a molybdenum-based X-ray source, which is not appropriate for making measurements on small and/or organic crystals. Thus, this proposal seeks funding for a critical upgrade to SFU's single-crystal X-ray diffractometer: the addition of a high-intensity copper-based microfocus X-ray source. This upgrade will greatly impact the research programs of most organic and inorganic chem. researchers at SFU by opening the door to obtaining high-quality structural data from small, weakly diffracting crystals and organic crystals.
This upgrade will support a wide range of research programs in SFU's chemistry department, including metal-coordination polymers for materials applications such as toxic gas sensors (Leznoff), organic nanomaterials for molecule-based circuit boards, photoactive therapeutics and drug-delivery vehicles (Branda), synthesis of new carbohydrate-based drugs (Bennet, Pinto) and of other natural products for human disease treatment (Britton), anti-cancer prodrugs (Walsby) and bimetallic oxidation catalysts for a range of molecular transformations (Storr). Each of these research areas critically require X-ray structure determinations from small, weakly diffracting crystals and/or organic crystals, which will become possible with the requested upgrade.
A substantial portion of SFU's Chemistry Dept. researchers will be impacted by this upgrade, and will be able to receive valuable hands-on training in determining molecular structures using single-crystal X-ray diffraction, as well as the safe use of X-ray infrastructure.
