Grant: CIHR Fellowship
Centre hospitalier de l'Université de Montréal (CHUM)
$112,500.00
Expression of catenins in the blood brain barrier and their intercations with the adhesion molecule ALCAM: relevance to MS and EAE
EF 2008-09
Résumé
The Blood Brain Barrier (BBB) is composed of tightly bound endothelial cells that control the movement of blood-borne molecules and immune cells from the periphery into the brain. In neuroinflammatory conditions, such as those resulting from multiple sclerosis (MS), the BBB fails to prevent the movement of immune cells and pro-inflammatory mediators to the brain. The aim of this research is to gain a better understanding of the interactions between the structural components controlling the BBB properties of endothelial cells and the molecular elements needed by immune cells to migrate into the brain during the course of MS
Programme
CIHR Fellowship
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
181312
Name
Alvarez Jorge I
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Expression of catenins in the blood brain barrier and their intercations with the adhesion molecule ALCAM: relevance to MS and EAE
Programtype2
Fellowship Programs
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$112,500
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Adherens Junctions; Adhesion Molecules; Blood Brain Barrier; Co-Immunoprecipitation; Confocal Microscopy; Experimental Autoimmune Encephalitis; Histological Analysis; Immunofluorescence; Multiple Sclerosis; Western Blot
Abstract
The Blood Brain Barrier (BBB) is composed of tightly bound endothelial cells that control the movement of blood-borne molecules and immune cells from the periphery into the brain. In neuroinflammatory conditions, such as those resulting from multiple sclerosis (MS), the BBB fails to prevent the movement of immune cells and pro-inflammatory mediators to the brain. The aim of this research is to gain a better understanding of the interactions between the structural components controlling the BBB properties of endothelial cells and the molecular elements needed by immune cells to migrate into the brain during the course of MS
Competitiondate
200902
Approvedterm2
2 yrs 6 mths
Pinamesdelim
Alvarez, Jorge I
Approvedterm
2 ans 6 mois
Cihrcontribution2
~ $112,500~ $0~
