Grant: Project Grant
University of Alberta
$244,640.00
Visualizing stochastic protein misfolding to understand the origins of sporadic Tauopathies
EF 2015-16
Résumé
Dementias are ultimately caused by protein molecules getting into the wrong shape. This type of disease already presents a tremendous challenge to the health care system and families of affected patients, with patient numbers set to triple by 2050. Most dementias are unrelated to family histories and instead occur on a one-by-one basis in a seemingly unpredictable manner; this pattern of appearance is called "sporadic". We need to understand this sporadic process as it lies right at the headwaters of the whole degenerative process. In line with the crucial role of protein shape, we have been able to see protein misfolding as it first appears in a common type of dementia called a "tauopathy". We propose to build on the breakthrough of seeing a disease as first appears.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
347409
Name
Westaway David
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Visualizing stochastic protein misfolding to understand the origins of sporadic Tauopathies
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$244,640
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Aging; Neuroanatomy; Neurodegeneration; Preclinical Phase; Prion-Like Diseases; Protein Misfolding; Proteostasis; Sporadic Manifestation; Tau; Transgenics
Abstract
Dementias are ultimately caused by protein molecules getting into the wrong shape. This type of disease already presents a tremendous challenge to the health care system and families of affected patients, with patient numbers set to triple by 2050. Most dementias are unrelated to family histories and instead occur on a one-by-one basis in a seemingly unpredictable manner; this pattern of appearance is called "sporadic". We need to understand this sporadic process as it lies right at the headwaters of the whole degenerative process. In line with the crucial role of protein shape, we have been able to see protein misfolding as it first appears in a common type of dementia called a "tauopathy". We propose to build on the breakthrough of seeing a disease as first appears.
Competitiondate
201603
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Westaway, David
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $244,640~ $0~
