Grant: Project Grant
University of Toronto
$860,626.00
Corticospinal descending modulation of spinal sensory transduction in chronic pain
EF 2018-19
Résumé
Chronic pain is a severe medical condition that causes long-term suffering for patients, with no effective treatment available. This proposal aims to understand how the brain, or cortex, may affect pain transmission at the level of the spinal cord, a key 'gating' site for the amount of nociceptive information into the brain. We hypothesize that long-term descending facilitation of spinal pain transmission and cortical influences may contribute to chronic pain. New information learned from this proposal may help us to design better treatment for patients with chronic pain.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
401279
Name
Zhuo Min
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - C: Behavioural Studies, Neuroscience and Cognition
Projecttitle
Corticospinal descending modulation of spinal sensory transduction in chronic pain
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$860,626
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Anterior Cingulate Cortex; Descending Facilitation; Descending Inhibition; Glutamatergic Synapse; Inflammatory Pain; Neurophathic Pain; Optogenetic Stimulation; Rats; Spinal Dorsal Horn; Whole Cell Patch Clamp
Abstract
Chronic pain is a severe medical condition that causes long-term suffering for patients, with no effective treatment available. This proposal aims to understand how the brain, or cortex, may affect pain transmission at the level of the spinal cord, a key 'gating' site for the amount of nociceptive information into the brain. We hypothesize that long-term descending facilitation of spinal pain transmission and cortical influences may contribute to chronic pain. New information learned from this proposal may help us to design better treatment for patients with chronic pain.
Competitiondate
201903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Zhuo, Min
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $860,626~ $0~
