Grant: Engage Grants Program
St. Francis Xavier University
$25,000.00
Structure-Activity Relationship Studies of Fuscol to Identify Synthetically Accessible Anti-inflammatory Compounds
EF 2012-13
Résumé
The area of natural product research has been a fertile area of investigation providing compounds useful in
human health. Once a compound of interest has been discovered, the problem can often become an issue of
supply, particularly when the source of compound is a unique natural resource such as a marine coral. Organic
synthesis provides a method of obtaining bioactive natural products and has the added benefit of being able to
access unnatural analogues.
This project aims to prepare a series of synthetic analogs of an anti-inflammatory natural product in partnership
with a PEI-based company, Nautilus. By identification of the active component on the parent compound,
chemical features not required for activity will be synthetically truncated, simplifying the overall preparation
and cost of production. By accessing anti-inflammatory compounds synthetically instead of by manual
harvesting, this project aims to improve the economic and environmental feasibility of this potent, natural
product derived compound.
Programme
Engage Grants Program
Bénéficiaire
Emplacement
Nova Scotia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
435328-2012
Name nom
Derksen, Darren
Department département
Chemistry
Organization id
83
Institution établissement
St. Francis Xavier University
Province en
Nova Scotia
Province fr
Nouvelle-Écosse
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2012
Competition year année de concours
2012
Award amount
25000
Program id
EGP
Program name en
Engage Grants Program
Program name fr
Programme de subventions d'engagement partenariat
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1551
Committee name en
Atlantic Internal Decision Committee
Committee name fr
Comité de décision interne pour l'Atlantique
Area of application code
504
Area of application group en
Manufacturing processes and products
Area of application group fr
Procédés et produits industriels
Area of application en
Human pharmaceuticals
Area of application fr
Produits pharmaceutiques administrables à l'homme
Research subject code
3703
Research subject group en
Organic chemistry
Research subject group fr
Chimie organique
Research subject en
Organic syntheses
Research subject fr
Synthèses organiques
Partie
1
Nb partie
1
Application title
Structure-Activity Relationship Studies of Fuscol to Identify Synthetically Accessible Anti-inflammatory Compounds
Keyword
NSERC
Application summary
The area of natural product research has been a fertile area of investigation providing compounds useful in
human health. Once a compound of interest has been discovered, the problem can often become an issue of
supply, particularly when the source of compound is a unique natural resource such as a marine coral. Organic
synthesis provides a method of obtaining bioactive natural products and has the added benefit of being able to
access unnatural analogues.
This project aims to prepare a series of synthetic analogs of an anti-inflammatory natural product in partnership
with a PEI-based company, Nautilus. By identification of the active component on the parent compound,
chemical features not required for activity will be synthetically truncated, simplifying the overall preparation
and cost of production. By accessing anti-inflammatory compounds synthetically instead of by manual
harvesting, this project aims to improve the economic and environmental feasibility of this potent, natural
product derived compound.
