Grant: Project Grant
McGill University
$677,025.00
Mobile DNA elements targeting the replication fork
EF 2017-18
Résumé
Almost half of our genome is made up of mobile DNA elements, also known as transposons. In humans, they are involved in neuronal development and are the cause of many debilitating diseases. In bacteria, they drive evolution, fitness and the spread of drug resistance. We study how the bacterial Tn7 transposon, which is particularly efficient at spreading in all kinds of environments, targets DNA and its consequences.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
370100
Name
Guarne Alba
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Mobile DNA elements targeting the replication fork
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$677,025
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biochemistry; Crystallography; Dna Replication; Electron Microscopy; Molecular Biology; Protein-Dna Interactions; Protein-Protein Interactions; Small-Angle X-Ray Scattering; Tn7 Transposition
Abstract
Almost half of our genome is made up of mobile DNA elements, also known as transposons. In humans, they are involved in neuronal development and are the cause of many debilitating diseases. In bacteria, they drive evolution, fitness and the spread of drug resistance. We study how the bacterial Tn7 transposon, which is particularly efficient at spreading in all kinds of environments, targets DNA and its consequences.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Guarne, Alba
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $677,025~ $0~
