Grant: Project Grant
University of Toronto
$887,400.00
A general strategy to develop inhibitors for transcription factors
EF 2017-18
Résumé
Most current drugs focus only on a few established target proteins. Transcription factors are both one of the largest and one of the most important groups of proteins in humans. For instance, a large fraction of cancers are caused by aberrations in transcription factors. However, to date no drug that targets them has been developed. We are here proposing a novel integrated strategy to develop inhibitors to transcription factors that would potentially establish a whole new class of drugs.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
380690
Name
Kim Philip M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
A general strategy to develop inhibitors for transcription factors
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$887,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacterial-One-Hybrid; Drug Discovery; Protein Design; Transcription Factor; Yeast-Two-Hybrid
Abstract
Most current drugs focus only on a few established target proteins. Transcription factors are both one of the largest and one of the most important groups of proteins in humans. For instance, a large fraction of cancers are caused by aberrations in transcription factors. However, to date no drug that targets them has been developed. We are here proposing a novel integrated strategy to develop inhibitors to transcription factors that would potentially establish a whole new class of drugs.
Competitiondate
201803
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kim, Philip M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $887,400~ $0~
