Grant: Discovery Grants Program - Individual
University of British Columbia
$80,000.00
Medicinal inorganic chemistry
EF 2010-11
Résumé
Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions, broad spectrum of ligand systems, panoply of techniques and collaborations, and various sources of financial support. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, EPR, electrochemistry, NMR, MS etc.) and biological studies are undertaken in the research programme. The success of this approach is the imminent entry of bis(ethylmaltolato)oxovanadium(IV) (also known as BEOV or AKP-020) into a phase IIa clinical trial in type 2 diabetes (www.akesis.com) - basic NSERC- and CIHR-funded research in coordination chemistry and pharmacology has yielded a clinically studied drug and potential oral therapy.
This application is a long-term vision in medicinal inorganic chemistry, comprising four projects:
1. Glycosylated Pro-drugs for Metal Passivation in Neurodegenerative Disease
2. Carbohydrate Conjugates in Nuclear Medicine
3. Ferrocenyl-carbohydrate Conjugates in Malaria
4. Lanthanide Compounds for Bone Resorption Disorders
Programme
Discovery Grants Program - Individual
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
42394-2008
Name nom
Orvig, Chris
Department département
Chemistry
Organization id
2
Institution établissement
University of British Columbia
Province en
British Columbia
Province fr
Colombie-Britannique
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2010
Competition year année de concours
2008
Award amount
80000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
24
Committee name en
Inorganic & Organic Chemistry
Committee name fr
Chimie inorg. et org.
Area of application code
1202
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Physical sciences
Area of application fr
Sciences physiques
Research subject code
3603
Research subject group en
Inorganic chemistry
Research subject group fr
Chimie inorganique
Research subject en
Bio-inorganic chemistry
Research subject fr
Chimie bio-inorganique
Partie
3
Nb partie
5
Application title
Medicinal inorganic chemistry
Keyword
NSERC
Application summary
Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions, broad spectrum of ligand systems, panoply of techniques and collaborations, and various sources of financial support. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, EPR, electrochemistry, NMR, MS etc.) and biological studies are undertaken in the research programme. The success of this approach is the imminent entry of bis(ethylmaltolato)oxovanadium(IV) (also known as BEOV or AKP-020) into a phase IIa clinical trial in type 2 diabetes (www.akesis.com) - basic NSERC- and CIHR-funded research in coordination chemistry and pharmacology has yielded a clinically studied drug and potential oral therapy.
This application is a long-term vision in medicinal inorganic chemistry, comprising four projects:
1. Glycosylated Pro-drugs for Metal Passivation in Neurodegenerative Disease
2. Carbohydrate Conjugates in Nuclear Medicine
3. Ferrocenyl-carbohydrate Conjugates in Malaria
4. Lanthanide Compounds for Bone Resorption Disorders
