Grant: Master's Award: Canada Graduate Scholarships
Research Institute of the McGill University Health Centre
$17,500.00
Establishment and Stability of DNA Methylation Patterns in the Male Germline
EF 2010-11
Résumé
In sperm cell development there is a pattern of chemical modifications (methylation) that occurs at specific points throughout the genome. This pattern is established in the embryo and shortly after birth. However in germ cell (sperm and egg) development there is an erasure of these patterns and then a re-establishment. These modifications which effect the expression of certain genes (epigenetics) may be disrupted when the enzyme that adds the modifications are not properly functioning or sometimes due to environmental factors these patterns are also not properly established. Our goal is to correct these mis-established patterns which would ultimately lead to correct sperm cell development, and embryo development.
Programme
Master's Award: Canada Graduate Scholarships
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
225086
Name
Farag Mena
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Canada Graduate Scholarships Master's Awards A
Projecttitle
Establishment and Stability of DNA Methylation Patterns in the Male Germline
Programtype2
Studentship Programs
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$17,500
Cihrequipment2
$0
Programname2
Master's Award: Canada Graduate Scholarships
Keyworddelim
Cell Culture; Developmental Genetics; Dna Methyl Transferase (Dnmt); Dna Methylation; Embryogenesis; Epigenetics; Restriction Landscape Genomic Sequencing (Rlgs); Retroviral Transfection; Spermatogenesis; Transgenic Mouse Model
Abstract
In sperm cell development there is a pattern of chemical modifications (methylation) that occurs at specific points throughout the genome. This pattern is established in the embryo and shortly after birth. However in germ cell (sperm and egg) development there is an erasure of these patterns and then a re-establishment. These modifications which effect the expression of certain genes (epigenetics) may be disrupted when the enzyme that adds the modifications are not properly functioning or sometimes due to environmental factors these patterns are also not properly established. Our goal is to correct these mis-established patterns which would ultimately lead to correct sperm cell development, and embryo development.
Competitiondate
201102
Approvedterm2
1 yr 0 mth
Pinamesdelim
Farag, Mena
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $17,500~ $0~
