Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
University of British Columbia
$105,000.00
Identification of drivers of metastasis in Ewing sarcoma using next-generation sequencing technologies
EF 2012-13
Résumé
Ewing sarcoma is the second most common bone/soft tissue cancer in children and adolescents. Besides a few genetic mutations known to cause the primary tumour, little is known about what promotes the aggressive progression of Ewing sarcoma. Indeed, mutations that cause metastasis in Ewing sarcoma have remained utterly elusive. Children with metastatic Ewing sarcoma have a very poor outlook, with less than 20% survival rate. Sadly, this survival rate is further reduced to about 14% for patients with combined lung and bone/bone marrow metastases. Hence, there is an urgent need to identify the genetic causes of metastasis and to find and evaluate novel therapeutics that specifically target metastases in Ewing sarcoma. The principal aim of the proposed research is to discover the causes of metastasis in Ewing sarcoma using high-throughput DNA and RNA sequencing technologies and thereby to reveal new therapeutic options for fighting this grim childhood malignancy.
Programme
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
283799
Name
Zhan Shing H
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Identification of drivers of metastasis in Ewing sarcoma using next-generation sequencing technologies
Programtype2
Studentship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Ewing Sarcoma; Exome Sequencing; Metastasis; Next-Generation Sequencing; Transcriptome Sequencing
Abstract
Ewing sarcoma is the second most common bone/soft tissue cancer in children and adolescents. Besides a few genetic mutations known to cause the primary tumour, little is known about what promotes the aggressive progression of Ewing sarcoma. Indeed, mutations that cause metastasis in Ewing sarcoma have remained utterly elusive. Children with metastatic Ewing sarcoma have a very poor outlook, with less than 20% survival rate. Sadly, this survival rate is further reduced to about 14% for patients with combined lung and bone/bone marrow metastases. Hence, there is an urgent need to identify the genetic causes of metastasis and to find and evaluate novel therapeutics that specifically target metastases in Ewing sarcoma. The principal aim of the proposed research is to discover the causes of metastasis in Ewing sarcoma using high-throughput DNA and RNA sequencing technologies and thereby to reveal new therapeutic options for fighting this grim childhood malignancy.
Competitiondate
201210
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Zhan, Shing H
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
