Grant: Project Grant
Sunnybrook Research Institute (Toronto, Ontario)
$764,500.00
Establishing a Comprehensive Genetic Roadmap for Human Pancreatic Beta Cell Proliferation and Function
EF 2015-16
Résumé
Our vision is to establish a complete understanding of the biology of human ß cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabetes mellitus (DM), and affects over 13M Canadians. While it is widely held that treating DM will require improving the health of the human ß cell, our current knowledge of the basic properties of the human ß cell are lacking. We will use cutting-edge technology to provide a complete understanding of how both mature adult human ß cells and their stem cell precursors grow, divide and secrete insulin. Furthermore, we will explore targeting a novel pathway we discovered that when activated increases beta cell function in response to high sugar levels for prevention and treatment of DM.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
346453
Name
Screaton Robert A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Establishing a Comprehensive Genetic Roadmap for Human Pancreatic Beta Cell Proliferation and Function
Programtype2
Operating Grants
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$764,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cell Biology; Cell Cycle; Diabetes; High Content Imaging; High Throughput Screening (Hts); Human Beta Cells; Human Islets; Rna Interference; Type I
Abstract
Our vision is to establish a complete understanding of the biology of human ß cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabetes mellitus (DM), and affects over 13M Canadians. While it is widely held that treating DM will require improving the health of the human ß cell, our current knowledge of the basic properties of the human ß cell are lacking. We will use cutting-edge technology to provide a complete understanding of how both mature adult human ß cells and their stem cell precursors grow, divide and secrete insulin. Furthermore, we will explore targeting a novel pathway we discovered that when activated increases beta cell function in response to high sugar levels for prevention and treatment of DM.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Screaton, Robert A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $764,500~ $0~
