Grant: Team Grant: HIV/AIDS Biomedical and Clinical Research - Prevention - Focused
University of Manitoba
$1,999,840.00
The microbiome in HIV prevention
EF 2018-19
Résumé
The microbiome has been associated with increased risk of HIV acquisition, but this has not been studied extensively in the context of HIV prevention technologies, such as antiretroviral based pre-exposure prophylaxis and vaccines. In this study we will evaluate how differences in the microbiome of genital tract and gut affect host inflammation, the effectiveness of these drugs, and immune responses stimulated by HIV vaccines. These studies may help us to improve these products to make them more effective for HIV prevention.
Programme
Team Grant: HIV/AIDS Biomedical and Clinical Research - Prevention - Focused
Bénéficiaire
Emplacement
Manitoba, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
404214
Name
Burgener Adam
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Team Grant : HIV/AIDS Biomedical and Clinical Research
Projecttitle
The microbiome in HIV prevention
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$1,999,840
Cihrequipment2
$0
Programname2
Team Grant: HIV/AIDS Biomedical and Clinical Research - Prevention - Focused
Keyworddelim
Hiv/Aids; Microbiome; Mucosal Immunity; Pre-Exposure Prophylaxis; Proteomics; Vaccines
Abstract
The microbiome has been associated with increased risk of HIV acquisition, but this has not been studied extensively in the context of HIV prevention technologies, such as antiretroviral based pre-exposure prophylaxis and vaccines. In this study we will evaluate how differences in the microbiome of genital tract and gut affect host inflammation, the effectiveness of these drugs, and immune responses stimulated by HIV vaccines. These studies may help us to improve these products to make them more effective for HIV prevention.
Competitiondate
201811
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Burgener, Adam; Herrera, Carolina; Paredes, Roger
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,999,840~ $0~
