Grant: Operating Grant

Mitochondria are the organelles responsible for energy (ATP) production in most cell types. As we age, there is evidence that mitochondrial function is impaired and that the concentration of mitochondria in muscle cells is reduced. This can result in poor energy production, fatigue and decreased quality of life. However, the reasons for the reduced mitochondrial concentration and function are not well known. In addition, evidence exists that exercise prevents this decrease, but the underlying mechanisms are not established. These questions will be addressed in the current research proposal. This work is important for our understanding of how exercise can improve musculoskeletal health during the aging process.