Grant: Project Grant

Flu is a contagious respiratory illness caused by influenza viruses that infect the nose, throat, and sometimes the lungs. It can cause mild to severe disease and, at times, can lead to death, especially in vulnerable populations such as young children, older adults, people with underlying diseases (like obesity, asthma), and immunocompromised patients. The goal of our research is to improve treatment of immunocompromised patients infected with influenza viruses. We will test the efficacy of commercially available anti-influenza drugs, which target different steps of the virus's life cycle, as well as anti-inflammatory medications that reduce harmful inflammation. We will examine how well these drugs work on their own and in combination. To do this, we use laboratory models that represent both healthy individuals and those with weakened immune systems, allowing us to study how treatments might work in different types of patients. Our research addresses an important gap in knowledge about how best to treat influenza in vulnerable populations. The results of this work will help guide doctors and public health authorities in choosing effective therapeutic options for high-risk patients who need treatment.