Grant: Discovery Grants Program - Individual
Memorial University of Newfoundland
$31,000.00
PIWI-interacting RNA-guided somatic gene regulation in cell homeostasis and differentiation
EF 2023-24
Résumé
In the late nineties, researchers uncovered a new cellular pathway in animals which is triggered by duplex RNA molecules and controls the flow of genetic information. This breakthrough discovery called RNA interference (RNAi) was acknowledged by the Nobel Committee in 2006 for its potential in the development of novel RNA-based technologies based on small non-coding RNAs (sncRNAs) that will be extremely useful for biological research and industrial application. My research group will investigate the role of sncRNA named PIWI-interacting RNA (piRNA) in gene regulation using human and mouse cell lines, including those with regenerative capacity to understand their complex mechanisms defining cellular characteristics and function. I believe that this innovative research program will contribute to unveil the importance of piRNAs in determining cellular identity and support the use of piRNAs as molecular tools in research laboratories and industries focused on life science and biomedicine.
Programme
Discovery Grants Program - Individual
Bénéficiaire
Emplacement
Newfoundland and Labrador, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
RGPIN-2022-03780
Name nom
Kakumani, Pavan Kumar
Department département
Biochemistry
Organization id
89
Institution établissement
Memorial University of Newfoundland
Province en
Newfoundland and Labrador
Province fr
Terre-Neuve-et-Labrador
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2022
Award amount
31000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
1501
Committee name en
Genes, Cells and Molecules
Committee name fr
Gènes, cellules et molécules
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Not available
Research subject en
Non disponible
Research subject fr
Non disponible
Application title
PIWI-interacting RNA-guided somatic gene regulation in cell homeostasis and differentiation
Keyword
cell culture; cellular differentiation; gene regulation; mammals; molecular biology; mRNA; piRNA; RNA silencing; small RNAs; transposable elements
Application summary
In the late nineties, researchers uncovered a new cellular pathway in animals which is triggered by duplex RNA molecules and controls the flow of genetic information. This breakthrough discovery called RNA interference (RNAi) was acknowledged by the Nobel Committee in 2006 for its potential in the development of novel RNA-based technologies based on small non-coding RNAs (sncRNAs) that will be extremely useful for biological research and industrial application. My research group will investigate the role of sncRNA named PIWI-interacting RNA (piRNA) in gene regulation using human and mouse cell lines, including those with regenerative capacity to understand their complex mechanisms defining cellular characteristics and function. I believe that this innovative research program will contribute to unveil the importance of piRNAs in determining cellular identity and support the use of piRNAs as molecular tools in research laboratories and industries focused on life science and biomedicine.
