Grant: CIHR New Investigator

Every cell in our bodies contains the same genetic material yet cells are functionally very different, expressing distinct genes and, consequently, distinct proteins. Regulating gene expression at the correct time and in response to the correct signals is critical to the proper function of each cell in our bodies. Many diseases, including all cancers, occur as the result of dramatic changes in gene expression. Despite the importance of proper gene regulation, the key DNA sequences that regulate many genes have not been identified. These sequences are often hidden in large stretches of the genome that are devoid of genes and as a result are difficult to find. Recent technical advances have allowed identification of these sequences with greater ease but questions remain as to which specific genes are regulated by specific DNA elements. By using new techniques that identify folds in the genome that bring sequences associated with gene regulation close to the gene, this project will identify the genetic elements that regulate specific genes. We will also investigate the proteins that are mediating these folding interactions in the genome. Through a better understanding of how specific genes are regulated in each cell type we will be better able to understand diseases that arise as a result of aberrant gene expression.