Grant: Alliance Grants
University of Windsor
$50,000.00
Development of lab on a chip for rapid and accurate point of care detection of COVID-19_x000d_ _x000d_
EF 2020-21
Résumé
Until a vaccine is developed, the ability to reduce the transmission of COVID-19 is directly dependent on the capacity to test and isolating the infected. Currently, COVID-19 testing is performed in a sophisticated laboratory setup that requires time and sample routing to designated labs. Accurate, rapid, onsite and point of care (POC) detection has paramount importance not only in Canada but also worldwide for early intervention and infection control. Development of such a device will be highly impactful for our fight against COVID-19. Most of the COVID-19 test are based on quantitative reverse transcription polymerase chain reaction (qRT-PCR) of the virus RNA. PCR takes hours to reach a result and requires laboratory settings. Portable isothermal nucleic acid amplification and loop-mediated isothermal amplification (LAMP) systems are fast but not suitable for wide usage due to the higher cost. Alternately, antibody based POCs offer cost-effective but it can only detect whether an individual has been previously infected or not. These drawbacks in the current technologies are hindering the fight a contagious virus such as COVID-19, tests must be quick (minutes not hours), cost effective, portable and be highly accurate to identify infected persons and control transmission. In partnership with APAG Elektronik Corp, a national leader in the manufacturing of electronics and lighting components, we will design and produce a semiconductor-based lab-on-a-chip detection that is based on electrical sensing and detection of viral loads. This non-PCR technique will detect the virus from the electrical signal generated from the binding of COVID-19 virus S protein with human angiotensin converting enzyme-2 (ACE2) protein. The device will be rapidly manufacturable via a combination of cost-effective 3D printing, screen printing and integrated electrical readout. This NSERC Alliance grant will be a first-time collaboration between the research team from the University of Windsor and APAG Elektronik Corp to develop a new method for COVID-19 point of care testing by combining the sensor development skills of the applicants and the electronic manufacturing and distribution skills of the industry partner.
Programme
Alliance Grants
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
552043-2020
Name nom
Ahamed, Mohammed
Department département
Mechanical, Automotive and Materials Engineering
Organization id
37
Institution établissement
University of Windsor
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2020
Competition year année de concours
2020
Award amount
50000
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
1206
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Engineering
Area of application fr
Génie
Research subject code
2109
Research subject group en
Mechanical engineering
Research subject group fr
Génie mécanique
Research subject en
Mechanical systems and instrumentation
Research subject fr
Instrumentation et systèmes mécaniques
Installment
inst:1 - 1
Partie
1
Nb partie
1
Application title
Development of lab on a chip for rapid and accurate point of care detection of COVID-19_x000d_
_x000d_
Keyword
NSERC
Application summary
Until a vaccine is developed, the ability to reduce the transmission of COVID-19 is directly dependent on the capacity to test and isolating the infected. Currently, COVID-19 testing is performed in a sophisticated laboratory setup that requires time and sample routing to designated labs. Accurate, rapid, onsite and point of care (POC) detection has paramount importance not only in Canada but also worldwide for early intervention and infection control. Development of such a device will be highly impactful for our fight against COVID-19. Most of the COVID-19 test are based on quantitative reverse transcription polymerase chain reaction (qRT-PCR) of the virus RNA. PCR takes hours to reach a result and requires laboratory settings. Portable isothermal nucleic acid amplification and loop-mediated isothermal amplification (LAMP) systems are fast but not suitable for wide usage due to the higher cost. Alternately, antibody based POCs offer cost-effective but it can only detect whether an individual has been previously infected or not. These drawbacks in the current technologies are hindering the fight a contagious virus such as COVID-19, tests must be quick (minutes not hours), cost effective, portable and be highly accurate to identify infected persons and control transmission. In partnership with APAG Elektronik Corp, a national leader in the manufacturing of electronics and lighting components, we will design and produce a semiconductor-based lab-on-a-chip detection that is based on electrical sensing and detection of viral loads. This non-PCR technique will detect the virus from the electrical signal generated from the binding of COVID-19 virus S protein with human angiotensin converting enzyme-2 (ACE2) protein. The device will be rapidly manufacturable via a combination of cost-effective 3D printing, screen printing and integrated electrical readout. This NSERC Alliance grant will be a first-time collaboration between the research team from the University of Windsor and APAG Elektronik Corp to develop a new method for COVID-19 point of care testing by combining the sensor development skills of the applicants and the electronic manufacturing and distribution skills of the industry partner.
