Grant: Alliance Grants
University of Prince Edward Island
$25,000.00
Hydrophilic Nano patterned Surfaces for Macrophage Polarization and Drug Delivery
EF 2022-23
Résumé
This project aims to explore the potential of nanopatterned hydrophilic surfaces for enhanced wound healing. Nanopatterned hydrophilic surfaces prepared using Cicada wing as template will be loaded with antibacterial and immunomodulatory peptides. The release of peptides from surfaces, their integrity and antibacterial properties will be studied in vitro, in simulated wound fluid. The peptide loaded nanopatterned surfaces will be cultured in the presence of macrophages and macrophage polarization capabilities of the surfaces, in the presence and absence of peptides will be studied. The nanopatterned surfaces with enhanced macrophage polarization capabilities and antibacterial efficacies in the presence and absence of peptide loading will be identified.
Programme
Alliance Grants
Bénéficiaire
Emplacement
Prince Edward Island, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
576948-2022
Name nom
Ahmed, Marya M
Department département
Chemistry
Organization id
88
Institution établissement
University of Prince Edward Island
Province en
Prince Edward Island
Province fr
Île-du-Prince-Édouard
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2022
Competition year année de concours
2022
Award amount
25000
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
1902
Research subject group en
Biomedical engineering
Research subject group fr
Génie biomédical
Research subject en
Biomedical materials
Research subject fr
Matériaux biomédicaux
Installment
inst:1
Partie
1
Nb partie
1
Application title
Hydrophilic Nano patterned Surfaces for Macrophage Polarization and Drug Delivery
Application summary
This project aims to explore the potential of nanopatterned hydrophilic surfaces for enhanced wound healing. Nanopatterned hydrophilic surfaces prepared using Cicada wing as template will be loaded with antibacterial and immunomodulatory peptides. The release of peptides from surfaces, their integrity and antibacterial properties will be studied in vitro, in simulated wound fluid. The peptide loaded nanopatterned surfaces will be cultured in the presence of macrophages and macrophage polarization capabilities of the surfaces, in the presence and absence of peptides will be studied. The nanopatterned surfaces with enhanced macrophage polarization capabilities and antibacterial efficacies in the presence and absence of peptide loading will be identified.
