Grant: Project Grant

The goal of this research project is to identify alternative therapeutic strategies to target breast cancers that are associated with poor patient outcomes. In order to divide, cancer cells require energy to build all of the components necessary for making new cells. Recent research has focused on how cancer cells meet the energy and resource requirements to sustain the needs of rapidly growing tumours, which is the study of cellular metabolism. Interestingly, the way cancer cells transform energy is quite different from that of normal cells. The goal of this application is to identify metabolic networks that drive the progression of poor outcome cancers. Our long-term goals are to identify metabolic vulnerabilities of cancer cells in order to develop potential cancer metabolic therapies that could be used either alone or in combination with other anti-cancer drugs.