Grant: Project Grant
McGill University
$1,044,226.00
TACAN is an ion channel essential for osteoarthritis pain
EF 2019-20
Résumé
Osteoarthritis (OA) afflicts more than 10% of Canadians. The cardinal symptom of this disease is chronic pain at rest or during movement. Clinical and preclinical research have indicated that OA pain emanates from hyper-responsive pain-sensing fibers (also called nociceptors). Yet the mechanisms underlying this hypersensitivity remain unknown. We have previously demonstrated that a subtype of sensors expressed in nociceptors become sensitized during OA and are responsible for the pain symptoms. However, the identity of these sensors remained elusive. We have now identified a protein, named TACAN, that acts as a sensor for painful stimuli. The current proposal aims at taking a translational approach to determine whether TACAN is responsible for OA pain and could constitute a valuable therapeutic target for OA pain.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
420310
Name
Sharif-Naeini Reza
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
TACAN is an ion channel essential for osteoarthritis pain
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,044,226
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Electrophysiology; Inflammation; Ion Channels; Mechanotransduction; Nociceptor; Osteoarthritis; Pain; Patch Clamp
Abstract
Osteoarthritis (OA) afflicts more than 10% of Canadians. The cardinal symptom of this disease is chronic pain at rest or during movement. Clinical and preclinical research have indicated that OA pain emanates from hyper-responsive pain-sensing fibers (also called nociceptors). Yet the mechanisms underlying this hypersensitivity remain unknown. We have previously demonstrated that a subtype of sensors expressed in nociceptors become sensitized during OA and are responsible for the pain symptoms. However, the identity of these sensors remained elusive. We have now identified a protein, named TACAN, that acts as a sensor for painful stimuli. The current proposal aims at taking a translational approach to determine whether TACAN is responsible for OA pain and could constitute a valuable therapeutic target for OA pain.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sharif-Naeini, Reza
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,044,226~ $0~
