Grant: Operating Grant
University of British Columbia
$915,000.00
The role of RCAN1 in Alzheimer pathogenesis
EF 2014-15
Résumé
Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly population. Patients with diabetes have a greater risk to develop AD and a majority of AD patients also have hyperglycemia. The mechanism linking diabetes to AD remains undefined. Progressive neuronal loss is one of the pathological features of AD. People with Down Syndrome having extra copy of chromosome 21 develop characteristic AD neuropathology after middle age and several genes on chromosome 21 including APP and the regulator of calcineurin 1 (RCAN1) are implicated in AD pathogenesis. Our preliminary studies suggest that RCAN1 promotes neurodegeneration and our working hypothesis is that abnormal RCAN1 expression and function contribute to Alzheimer pathogenesis. This proposal seeks to elucidate the molecular mechanism of RCAN1's effect on Alzheimer pathogenesis and define its role in linking diabetes to AD. The results will be of clinical significance and provide evidences for targeting RCAN1 in AD treatment.
Programme
Operating Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
321807
Name
Song Weihong
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Biological and Clinical Aspects of Aging
Projecttitle
The role of RCAN1 in Alzheimer pathogenesis
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$915,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Alzheimer'S Disease; Amyloid Beta Protein; Diabetes; Drug Dedevelopment; High Glucose; Neuronal Apoptosis; Racn1; Transgeneic Mice
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly population. Patients with diabetes have a greater risk to develop AD and a majority of AD patients also have hyperglycemia. The mechanism linking diabetes to AD remains undefined. Progressive neuronal loss is one of the pathological features of AD. People with Down Syndrome having extra copy of chromosome 21 develop characteristic AD neuropathology after middle age and several genes on chromosome 21 including APP and the regulator of calcineurin 1 (RCAN1) are implicated in AD pathogenesis. Our preliminary studies suggest that RCAN1 promotes neurodegeneration and our working hypothesis is that abnormal RCAN1 expression and function contribute to Alzheimer pathogenesis. This proposal seeks to elucidate the molecular mechanism of RCAN1's effect on Alzheimer pathogenesis and define its role in linking diabetes to AD. The results will be of clinical significance and provide evidences for targeting RCAN1 in AD treatment.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Song, Weihong
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $915,000~ $0~
