Grant: Foundation Grant
University of Toronto
$2,848,146.00
Mechanisms of Genome Instability
EF 2017-18
Résumé
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells (mutations, for example). These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how changes to the DNA arise could lead to improvements in cancer detection and treatment, and is also relevant to ageing, where mistakes in the DNA happen more often. We will study how proteins help copy the DNA, how proteins prevent mistakes during the copying of the DNA, and will apply this knowledge to discover new ways to prevent the kinds of mistakes that can lead to human diseases, including cancers.
Programme
Foundation Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
369112
Name
Brown Grant W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Foundation Grant
Projecttitle
Mechanisms of Genome Instability
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$2,848,146
Cihrequipment2
$0
Programname2
Foundation Grant
Keyworddelim
Chromosome Transmission; Dna Damage; Dna Repair; Dna Replication; Functional Genomics; Genetics; Genome Instability; High Content Imaging; Model Organisms; Single Molecule Analysis
Abstract
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells (mutations, for example). These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how changes to the DNA arise could lead to improvements in cancer detection and treatment, and is also relevant to ageing, where mistakes in the DNA happen more often. We will study how proteins help copy the DNA, how proteins prevent mistakes during the copying of the DNA, and will apply this knowledge to discover new ways to prevent the kinds of mistakes that can lead to human diseases, including cancers.
Competitiondate
201709
Approvedterm2
7 yrs 0 mth
Pinamesdelim
Brown, Grant W
Approvedterm
7 ans 0 mois
Cihrcontribution2
~ $2,848,146~ $0~
