Grant: Project Grant

Because more than 30% of male infertility cases are of unknown origin, it is crucial to identify the molecular factors controlling the male reproductive system. The epididymis is a long tubule located downstream of the testis in charge of the acquisition of sperm fertilizing ability. It is therefore an exquisite model for studying sequential events that transform an immature sperm cell into a fully motile and fertile spermatozoon. Recently, primary cilia have been found associated with epithelial cells of the epididymis. These organelles are unique antennae that emerge on the surface of cells and are mediators of many signaling pathways involved in differentiation, proliferation and cell migration. In Human, primary cilia dysfunctions are associated with a broad spectrum of defects, including male infertility, that are commonly referred to ciliopathies. Since primary cilia are essential to maintain the physiological functions of most organs, our research project aims at unravelling the role of primary cilia in epididymis development and homeostasis. This innovative project combines complementary in vitro and in vivo approaches on cell lines and mouse models. Considering the importance of epididymal functions in the control of sperm fertilizing abilities, carrying out this research will help decipher the cellular functions that may be impaired in some cases of male infertility.