Grant: Operating Grant
Université Laval
$830,612.00
Detailed functional study of Argonaute proteins in microRNA-mediated gene regulation.
EF 2012-13
Résumé
RNA interference is a controlling pathway in cells that uses small biological molecules called RNA to abrogate the production of proteins. The very recent discovery of this new process have rapidly contributed to better understand different aspects of biology as well as to bring realistic hopes for the development of new types of treatments to cure several human diseases as acknowledged by the Nobel committee in 2006. To use RNA interference has it full potential in laboratories and clinics, it is primordial to fully understand this new cellular pathway.
To achieve this, we propose in this project to study the proteins essential for this new process called Argonautes. The round worm as animal model will be put in contribution to decipher the functions of Argonaute proteins in cell.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
280493
Name
Simard Martin J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Detailed functional study of Argonaute proteins in microRNA-mediated gene regulation.
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$830,612
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Argonaute; C. Elegans Genetics; Gene Regulation; Microrna Pathway; Small Non-Coding Rna
Abstract
RNA interference is a controlling pathway in cells that uses small biological molecules called RNA to abrogate the production of proteins. The very recent discovery of this new process have rapidly contributed to better understand different aspects of biology as well as to bring realistic hopes for the development of new types of treatments to cure several human diseases as acknowledged by the Nobel committee in 2006. To use RNA interference has it full potential in laboratories and clinics, it is primordial to fully understand this new cellular pathway.
To achieve this, we propose in this project to study the proteins essential for this new process called Argonautes. The round worm as animal model will be put in contribution to decipher the functions of Argonaute proteins in cell.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Simard, Martin J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $830,612~ $0~
