Grant: Project Grant

In Canada, antimicrobial resistance is estimated to lead to thousands of deaths and annual medical care costs >$1 billion per year. New approaches are desperately needed to combat antimicrobial resistance. One approach is to develop new targets for antimicrobials by studying processes that are essential to bacterial survival. Bacterial cell division is an essential process and provides a target-rich environment for the development of the next generation of antimicrobials. We propose to use molecular, biochemical, imaging and in silico approaches to identify and understand proteins that are essential to the process of cell division and to aid in developing antimicrobials to target them.