Grant: Operating Grant

Alzheimer's Disease (AD) is the leading cause of dementia in the elderly, and causes an enormous financial and emotional burden on patients and their families. Our research has demonstrated that the amount of cholesterol carried on apolipoprotein E (apoE), the best-established risk factor for AD, determines how much A-beta, a neuropathological hallmark of AD, is deposited in AD brains. The proposed research will determine the potential of using certain compounds to remove A-beta from the brain, thereby forming the potential basis of a new therapeutic strategy to treat this devastating disease.