Grant: Project Grant
University of Toronto
$514,311.00
Activation of a cytosolic unfolded protein response to clear aggregating alpha-synuclein
EF 2018-19
Résumé
In Parkinson's Disease, a protein called alpha-synuclein forms aggregates that are toxic are result in the death of brain cells. We have discovered a new way by which cells control the folding of proteins, to avoid formation of toxic aggregates. We will explore how this new pathway that we call the "cytosolic unfolded protein response" or cUPR can inhibit the formation of these aggregates and also importantly their clearance. This could lead to the development of novel therapeutic avenues against Parkinson's disease.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
390178
Name
Girardin Stephen E
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Activation of a cytosolic unfolded protein response to clear aggregating alpha-synuclein
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$514,311
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Alpha-Synuclein; Parkinson'S Disease; Protein Aggregation; Unfolded Protein Response
Abstract
In Parkinson's Disease, a protein called alpha-synuclein forms aggregates that are toxic are result in the death of brain cells. We have discovered a new way by which cells control the folding of proteins, to avoid formation of toxic aggregates. We will explore how this new pathway that we call the "cytosolic unfolded protein response" or cUPR can inhibit the formation of these aggregates and also importantly their clearance. This could lead to the development of novel therapeutic avenues against Parkinson's disease.
Competitiondate
201809
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Girardin, Stephen E
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $514,311~ $0~
