Grant: CIHR-ICRH Travel Awards - ICRH / Vascular pool
University of Toronto
$1,500.00
The role of microRNAs in hypertrophic cardiomyopathy: insights from patient-derived induced pluripotent stem cell cardiomyocytes and myocardial tissue
EF 2023-24
Résumé
Hypertrophic cardiomyopathy (HCM) is a genetic condition involving the thickening of the heart muscle, leading to heart failure and sudden cardiac death. In our study, we investigated the role of microRNAs, which regulate gene expression, to potentially identify novel diagnostic and therapeutics targets for HCM. Using a stem cell model derived from patients with HCM as well as heart tissue, we discovered differential expression of microRNAs between healthy and diseased patients. Additionally, we observed variations in microRNA expression among patients with different mutations causing HCM.
Programme
CIHR-ICRH Travel Awards - ICRH / Vascular pool
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
495411
Name
Adao Doris M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Prcname2
Special Cases
Projecttitle
The role of microRNAs in hypertrophic cardiomyopathy: insights from patient-derived induced pluripotent stem cell cardiomyocytes and myocardial tissue
Programtype2
Undefined
Orgnameinp2
University of Toronto
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - ICRH / Vascular pool
Keyworddelim
Cardiomyopathy; Microrna
Abstract
Hypertrophic cardiomyopathy (HCM) is a genetic condition involving the thickening of the heart muscle, leading to heart failure and sudden cardiac death. In our study, we investigated the role of microRNAs, which regulate gene expression, to potentially identify novel diagnostic and therapeutics targets for HCM. Using a stem cell model derived from patients with HCM as well as heart tissue, we discovered differential expression of microRNAs between healthy and diseased patients. Additionally, we observed variations in microRNA expression among patients with different mutations causing HCM.
Competitiondate
202309
Approvedterm2
1 yr 0 mth
Pinamesdelim
Adao, Doris M
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,500~ $0~
