Grant: Operating Grant

Glypicans are proteins that regulate the activity of various families of growth factors including Hedgehogs. The activity of these growth factors is frequently altered in cancer and other genetic diseases. The goal of this project is to investigate the molecular mechanisms by which the various glypicans regulate the activity of Hedeghogs. We expect that a better understanding of the role of glypicans in the regulation of the activity of Hedgehogs will facilitate the development of therapies that target such growth factors in cancer and other genetic diseases.