Grant: Project Grant

We have recently identified that human protein Cystathionine gamma lyase (CTH) plays key roles in the development of many cancers including Ewing sarcoma, breast, prostate, stomach, bladder, and colon cancers among others. We propose to use sophisticated, AI-driven, computer modelling and X-ray-based structure determination techniques to specifically design drugs which bind to these proteins and prevent their functioning. This will reduce the cancer cells' ability to survive stress, and make the cancers more susceptible to complimentary treatments like chemo- and radiation therapies. This 1-2 punch will provide an extra treatment option, especially for cancers which currently lack any effective treatments like the childhood cancer Ewing Sarcoma. It also could allow for shorter lengths when paired with current chemo- and radiation options in other cancers. Ultimately this may be more effective and have fewer side effects than current treatments.