Grant: Travel Awards - Institute Community Support

FRK (Fyn-related kinase) is a non-receptor tyrosine kinase that belongs to the BRK (Breast tumor kinase) family. Previous studies as well as current studies in our lab have shown that FRK pays a candidate tumor suppressor role in glioblastomas. Our studies have further shown that FRK suppresses cell growth and migration in a kinase-dependent manner. In the present study, we used quantitative phosphoproteomics analysis and identified the candidate substrates of FRK in glioblastoma cells. Our study is the first to identify the vast array of novel FRK candidate substrates which further reveals novel mechanisms by which FRK promotes tumor suppressor functions in glioblastoma cells.