Grant: Applied Research and Development Grants - Level 2
Douglas College
$27,975.00
Evaluation of diagnostic parameters for iatrogenic hypothyroidism in cats following treatment with radioactive iodine
EF 2014-15
Résumé
Hyperthyroidism (due to too much thyroid hormone) is a common disease in elderly cats that can be treatedwith radioactive-iodine (RAI). Over-treatment with RAI commonly results in low thyroid hormoneconcentrations however symptoms of hypothyroidism (due to insufficient thyroid hormones) are uncommonand the clinical significance of treatment-induced hypothyroidism in cats is debated. This has resulted in a lackof research into the diagnosis and treatment of this problem. However chronic kidney disease is more commonin cats with treatment-induced hypothyroidism and recent data shows that this adversely impacts the survival ofaffected cats.Treated hyperthyroid cats are currently monitored using total thyroxine (tT4) and other tests of thyroid functionsuch as free T4 (fT4) and TSH are not routinely ordered. The principal aim of this study is to compare theavailable thyroid hormone analyses (tT4, fT4 and TSH) with a reference test of thyroid function (TSHstimulation test) to refine diagnostic criteria for iatrogenic hypothyroidism.For this study 80-120 RAI-treated hyperthyroid cats will have a baseline thyroid and kidney function analysisand be assessed for symptoms of hypothyroidism. Subsequently, a subset of these cats including all those withabnormal thyroid hormone results, will have a TSH stimulation test done. In Year 2 and year 3 of the study thegeneral health and thyroid status of cats screened in year 1 will be reviewed annually. Health status andsurvival of hypothyroid RAI-treated cats will be compared to non-hypothyroid RAI-treated cats to determinethe clinical significance of this problem.This project will provide a unique opportunity for 6-8 final year Veterinary Technician students to participatein clinical research expanding their subsequent career opportunities. It is anticipated that the data will lead toincreased frequency and diversity of thyroid hormone testing in treated hyperthyroid cats with significantfinancial benefits to veterinarians, veterinary laboratories and RAI units.
Programme
Applied Research and Development Grants - Level 2
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
461094-2013
Name nom
Wakeling, Jennifer
Department département
Head Office
Organization id
28119
Institution établissement
Douglas College
Province en
British Columbia
Province fr
Colombie-Britannique
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2014
Competition year année de concours
2013
Award amount
27975
Program id
CARD2
Program name en
Applied Research and Development Grants - Level 2
Program name fr
Subventions de recherche et développement appliquée - niveau 2
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1561
Committee name en
Applied Research and Development Grants
Committee name fr
Subventions de recherche et développement appliquée
Area of application code
102
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Animal management (animal diseases, breeding)
Area of application fr
Gestion des animaux (maladies animales, reproduction)
Research subject code
5512
Research subject group en
Animal biology
Research subject group fr
Biologie animale
Research subject en
Veterinary sciences
Research subject fr
Médecine vétérinaire
Partie
1
Nb partie
3
Application title
Evaluation of diagnostic parameters for iatrogenic hypothyroidism in cats following treatment with radioactive iodine
Keyword
NSERC
Application summary
Hyperthyroidism (due to too much thyroid hormone) is a common disease in elderly cats that can be treatedwith radioactive-iodine (RAI). Over-treatment with RAI commonly results in low thyroid hormoneconcentrations however symptoms of hypothyroidism (due to insufficient thyroid hormones) are uncommonand the clinical significance of treatment-induced hypothyroidism in cats is debated. This has resulted in a lackof research into the diagnosis and treatment of this problem. However chronic kidney disease is more commonin cats with treatment-induced hypothyroidism and recent data shows that this adversely impacts the survival ofaffected cats.Treated hyperthyroid cats are currently monitored using total thyroxine (tT4) and other tests of thyroid functionsuch as free T4 (fT4) and TSH are not routinely ordered. The principal aim of this study is to compare theavailable thyroid hormone analyses (tT4, fT4 and TSH) with a reference test of thyroid function (TSHstimulation test) to refine diagnostic criteria for iatrogenic hypothyroidism.For this study 80-120 RAI-treated hyperthyroid cats will have a baseline thyroid and kidney function analysisand be assessed for symptoms of hypothyroidism. Subsequently, a subset of these cats including all those withabnormal thyroid hormone results, will have a TSH stimulation test done. In Year 2 and year 3 of the study thegeneral health and thyroid status of cats screened in year 1 will be reviewed annually. Health status andsurvival of hypothyroid RAI-treated cats will be compared to non-hypothyroid RAI-treated cats to determinethe clinical significance of this problem.This project will provide a unique opportunity for 6-8 final year Veterinary Technician students to participatein clinical research expanding their subsequent career opportunities. It is anticipated that the data will lead toincreased frequency and diversity of thyroid hormone testing in treated hyperthyroid cats with significantfinancial benefits to veterinarians, veterinary laboratories and RAI units.
