Grant: Project Grant
University of Toronto
$757,350.00
Collagen mineralization in the periodontium: from mechanism to tissue regeneration
EF 2021-22
Résumé
Periodontal disease is the most common infection in Canadian adults, and incidence is expected to increase as the population ages. In this disease, the attachment of teeth to the jawbone is destroyed by bacterial infection. Despite the high prevalence and significant economic burden of periodontal infections, there are major obstacles to effective and long- lasting treatment. In particular, reattachment of the ligament that connects to tooth root to the jawbone is still not possible. Here we propose to study the mechanism by which the ligament attaches to the root of the tooth in healthy teeth in order to design more effective strategies for achieving reattachment in treatment of periodontitis.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
452634
Name
Sone Eli D
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
Collagen mineralization in the periodontium: from mechanism to tissue regeneration
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$757,350
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biomineralization; Cementum; Crystal Nucleation And Growth; Extracellular Matrix; Glycosaminoglycans; Hydroxyapatite; In Situ Electron Microscopy; In Vitro Mineralization Model; Non-Collagenous Proteins; Tissue Engineering Scaffolds
Abstract
Periodontal disease is the most common infection in Canadian adults, and incidence is expected to increase as the population ages. In this disease, the attachment of teeth to the jawbone is destroyed by bacterial infection. Despite the high prevalence and significant economic burden of periodontal infections, there are major obstacles to effective and long- lasting treatment. In particular, reattachment of the ligament that connects to tooth root to the jawbone is still not possible. Here we propose to study the mechanism by which the ligament attaches to the root of the tooth in healthy teeth in order to design more effective strategies for achieving reattachment in treatment of periodontitis.
Competitiondate
202109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sone, Eli D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $757,350~ $0~
