Grant: Doctoral Research Award: Canada Graduate Scholarships

Glyphosate, the world's most widely used pesticide, has raised concerns for potential neurotoxic effects in adults, but its impact during pregnancy and early childhood remains poorly understood. Limited knowledge exists, especially for populations residing outside agricultural regions with lower direct exposure to glyphosate. This study aims to investigate the link between prenatal glyphosate exposure and cognitive and behavioural functioning in children living in non-agricultural areas. We will use data from an existing Canadian pregnancy and birth cohort: Maternal-Infant Research on Environmental Chemicals Study. Maternal glyphosate exposure was assessed using an established biomarker (i.e., urinary glyphosate concentration). Child intellectual abilities and behaviours were assessed at 3-4 years of age. Analyses will use advanced statistical models while accounting for relevant covariates. The study will also explore potential sex-based differences in children's vulnerability to prenatal glyphosate exposure and investigate maternal thyroid dysfunction as a possible underlying mechanism. This research is critical for advancing our understanding of the potential risks associated with prenatal glyphosate exposure, particularly for those living in non-agricultural settings. The findings will inform ongoing evaluations of glyphosate's toxicity, help identify vulnerable populations, and guide potential exposure reduction interventions.