Grant: CIHR-ICRH Travel Awards - ICRH / Vascular pool

Type 2 diabetes increases the risk of developing Alzheimer's disease and dementia, although the reasons are not entirely clear. The cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) pathway generates anti-inflammatory molecules, but these are quickly broken down into less beneficial forms by the sEH enzyme. These less beneficial molecules have previously been linked to cognitive problems in people with Alzheimer's disease, and this study has shown that they are also associated with worse cognition in people with diabetes. Targeting the sEH enzyme could potentially be a strategy to address cognitive symptoms in people with diabetes.