Grant: Engage Plus Grants Program

The objective of the company is to develop mixtures of natural products that can extend human lifespan andpromote healthy aging by delaying the onset of age-related diseases, including diabetes, cancer, cardiovascularand immune dysfunction, and neurodegeneration. To attain this challenging objective, the company needed arobust experimental approach for an assessment of the anti-aging efficiencies of numerous natural products thatcan be used as such mixtures. To address this challenge, the applicant used the initial Engage Grant funding for(1) developing an assay for yeast lifespan measurement as such approach; (2) employing the developed assayfor assessing the anti-aging efficiencies of 18 natural products provided by the company; and (3) conducting aquantitative evaluation of a possible synergy in lifespan extension between five most potent anti-aging naturalproducts revealed by the applicant and several currently known anti-aging natural compounds. The applicantnow seeks the Engage Plus Grant to support the project for an additional six months period while looking forlonger-term support. The goal of the proposed Engage Plus Grant project is to assess the anti-aging efficienciesof many other natural products provided in-kind by the company, as well as to test if complex mixtures of theseother natural products can mutually enhance the anti-aging efficiencies of several known longevity-extendingnatural compounds. The establishment of multicomponent mixtures of natural compounds exhibiting thehighest anti-aging efficiencies will have important implications for developing complex formulation of specificnatural products with the maximal aging-delaying, health-improving and lifespan-extending effects. Theproposed research project will further strengthen the existing relationship between the company and theapplicant. The project has the potential to be highly innovative and beneficial to the applicant's researchprogram by conceptually advancing the current understanding of molecular mechanisms and biologicalprinciples underlying the inherent complexity of cellular aging.