Grant: Research Tools and Instruments - Category 1 (<$150,000)

The present application seeks funding for equipment to support NSERC-funded research on the behavioural pharmacology of cannabinoids. Cannabis is the most widely used illicit drug in Canada and many other nations. Robust, often fiery, debate continues concerning the adverse consequences of cannabis use, as policy makers and the public grapple with issues of cannabis decriminalization and the use of cannabis for medicinal purposes. Fortunately for this debate, basic research on cannabis continues to evolve. We now know that cannabis and cannabis-like drugs (cannabinoids) produce their mind-altering effects by binding to and activating cannabinoid CB1 receptors, which are numerous and widespread in many brain regions. Another important recent finding was the discovery of endocannabinoids in the brain. These small lipid molecules play a critical role in information storage, movement, appetite, and the perception of pain. Endocannabinoid signaling has been linked to the development of schizophrenia, and in the development of addiction to non-cannabinoid drugs, such as alcohol and heroin. The present proposal seeks funds to purchase operant behaviour test equipment for experiments designed to elucidate the neural mechanisms by which endocannabinoids influence the development of drug addiction via the regulation of neuronal retrograde signaling. Information gained from this research will serve to inform medical and scientific communities, government policy makers, as well as the broader Canadian community about various key issues surrounding drug addiction, and on the critical role of the recently discovered endocannabinoid system.