Grant: Operating Grant

The degradation of proteins is necessary for the regulation of many cellular processes. Significantly, alterations in protein degradation have been linked to a number of important human diseases, including cancer. Proteins can be marked for degradation by the addition of a small protein called ubiquitin that is essential for the normal function of healthy cells. Given the importance of protein degradation, many viruses regulate protein degradation to their own advantage. Understanding how viruses regulate protein degradation will provide clues for the future development of therapeutic interventions.