Grant: Project Grant
University of British Columbia
$918,000.00
Harnessing infection-associated modifiers of paediatric acute lymphoblastic leukaemia progression for therapeutic benefit
EF 2023-24
Résumé
It has long been suspected that infections early in life can change an infant's risk of developing the blood cancer known as B-cell acute lymphoblastic leukemia (B-ALL) later in childhood. However, studies looking for the specific effects of infection in infants have been
inconclusive - results supporting both increased and decreased risk of B-ALL have been reported. Identifying the factors that dictate these different outcomes could help us understand the environmental drivers of B-ALL and provide a foundation for new treatment strategies. In this study, we will contribute to these goals by using a combination of mouse and human experimental systems to clarify the immune mechanisms that influence B-ALL progression.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
500163
Name
Reid Gregor
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Harnessing infection-associated modifiers of paediatric acute lymphoblastic leukaemia progression for therapeutic benefit
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$918,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Acute Lymphoblastic Leukemia; Early-Life Infection; Mouse Models Of Cancer; Neonatal Immunity; Pediatric Cancer; Pre-Clinical Therapy Development
Abstract
It has long been suspected that infections early in life can change an infant's risk of developing the blood cancer known as B-cell acute lymphoblastic leukemia (B-ALL) later in childhood. However, studies looking for the specific effects of infection in infants have been
inconclusive - results supporting both increased and decreased risk of B-ALL have been reported. Identifying the factors that dictate these different outcomes could help us understand the environmental drivers of B-ALL and provide a foundation for new treatment strategies. In this study, we will contribute to these goals by using a combination of mouse and human experimental systems to clarify the immune mechanisms that influence B-ALL progression.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Reid, Gregor
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $918,000~ $0~
