Grant: Project Grant
University of British Columbia
$100,000.00
A randomized, placebo-controlled trial of oral doxycycline for the prevention of syphilis in men who have sex with men (MSM)
EF 2016-17
Résumé
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Over the last decade, syphilis has seen a resurgence in many parts of the world, including Canada, with the bulk of infections seen in major urban centres. More recently, these increases have been even more significant, with a 30-40% rise in Vancouver and Toronto syphilis rates in 2015 compared to 2014. These infections have primarily affected men who have sex with men (MSM). Further, HIV-positive MSM are disproportionately affected by syphilis infections. In addition to playing a role in enhanced transmission of HIV, syphilis also places HIV-positive individuals at higher risk of complications and more severe disease. A recently published, small pilot study found that doxycycline - an inexpensive, relatively well-tolerated antibiotic - given daily may prevent new syphilis infections, along with other bacterial STIs such as chlamydia and gonorrhoea. This study will examine the use of doxycycline as daily preventative therapy for syphilis and other STIs in HIV-positive MSM.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
351808
Name
Grennan Jonathan (Troy)
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Gender and Health
Theme2
Clinical
Prcname2
Project Grant Competition
Projecttitle
A randomized, placebo-controlled trial of oral doxycycline for the prevention of syphilis in men who have sex with men (MSM)
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Human Immunodeficiency Virus (Hiv); Men Who Have Sex With Men (Msm); Pre-Exposure Prophylaxis (Prep); Prevention; Randomized Controlled Trial; Sexually Transmitted Infections (Sti); Syphilis
Abstract
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Over the last decade, syphilis has seen a resurgence in many parts of the world, including Canada, with the bulk of infections seen in major urban centres. More recently, these increases have been even more significant, with a 30-40% rise in Vancouver and Toronto syphilis rates in 2015 compared to 2014. These infections have primarily affected men who have sex with men (MSM). Further, HIV-positive MSM are disproportionately affected by syphilis infections. In addition to playing a role in enhanced transmission of HIV, syphilis also places HIV-positive individuals at higher risk of complications and more severe disease. A recently published, small pilot study found that doxycycline - an inexpensive, relatively well-tolerated antibiotic - given daily may prevent new syphilis infections, along with other bacterial STIs such as chlamydia and gonorrhoea. This study will examine the use of doxycycline as daily preventative therapy for syphilis and other STIs in HIV-positive MSM.
Competitiondate
201604
Approvedterm2
1 yr 0 mth
Pinamesdelim
Grennan, Jonathan (Troy); Tan, Darrell H; Wong, Jason
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
