Grant: CIHR-ICRH Travel Awards - General pool

D-mannose, a natural sugar, had previously shown promise in altering gut bacteria and preventing obesity. This study focused on whether it could also combat artery-clogging atherosclerosis. In mice genetically predisposed to artery problems, D-mannose was added to those on a high-fat diet. Strikingly, mice with D-mannose had fewer artery blockages. Notably, D-mannose appeared to reverse changes in gut bacteria caused by the high fat diet. In short, D-mannose might offer protection against artery issues, potentially tied to its influence on gut bacteria. These findings spotlight a novel avenue for promoting heart health.