Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$699,520.00
The molecular heritage of vascular injury: Roles in rejection and renal failure
EF 2015-16
Résumé
Our group showed that cells from damaged blood vessels send alarm signals to the immune system in the form of tiny cell fragments. The latter activate the immune system and accelerate rejection of transplanted organs. The goal of the present proposal is to characterize the basic pathways that control the production of these cell fragments, to characterize the mechanisms implicated in the activation of the immune system by these fragments and to evaluate the impact of these cell fragments on rejection and renal failure in renal transplant patients.
Programme
Project Grant
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
344472
Name
Hébert Marie-Josée
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
The molecular heritage of vascular injury: Roles in rejection and renal failure
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$699,520
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Apoptosis; Auto-Immunity; Autophagy; Cohort Studies; Complement; Exosomes; Proteomics; Rejection; Renal Failure; Vascular Injury
Abstract
Our group showed that cells from damaged blood vessels send alarm signals to the immune system in the form of tiny cell fragments. The latter activate the immune system and accelerate rejection of transplanted organs. The goal of the present proposal is to characterize the basic pathways that control the production of these cell fragments, to characterize the mechanisms implicated in the activation of the immune system by these fragments and to evaluate the impact of these cell fragments on rejection and renal failure in renal transplant patients.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hébert, Marie-Josée
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $699,520~ $0~
