Grant: Catalyst Grant: SPOR Innovative Clinical Trials (iCT)

The sleep-wake cycle is severely disrupted during an episode of mania. Often mania is treated with medications that can come with significant side effects. Years of patient and family engagement with this population have revealed great interest in therapies targeting the sleep-wake cycle. However, there is still a lack of studies to support using these treatments for mania. Patient partners are especially interested in two specific therapies for mania, blue-block glasses and time-restricted eating, because of their perceived feasibility and safety. This pilot study will formally investigate the feasibility and effectiveness of these therapies for participants with mania, an understudied population that faces many difficulties even after recovery. The pilot study will collect interviews to identify barriers and ways to better support patients with mania using the therapies. The study will also investigate how well these therapies can treat manic symptoms and restore sleep-wake cycles by tracking symptom rating scales and measuring activity levels. Results from this pilot will be used to direct a larger study. This larger study will use a state-of-the art design to test the effectiveness of both therapies alone and in combination. The planning and designing of this pilot study was done in collaboration with patient partners from the first meeting. The study will continue to engage patient partners throughout. Costs will also be reduced by using existing Canadian Institutes of Health Research supported initiatives for patient-oriented research.