Grant: Project Grant
McGill University
$497,250.00
Compounds blocking FIAT activity increase osteogenesis
EF 2019-20
Résumé
There is a need for developing treatments to stimulate bone formation in regenerative medicine since the approved drugs can only be used for a maximum of two years and have potential high risk side effects. We have developed assays that identified two lead compounds (small molecules) for the development of drugs that could stimulate bone formation. We will further characterize the mechanism of action of these compounds and test their safety and efficacy to increase bone mass and strength in preclinical models.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
418144
Name
St-Arnaud René
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
Compounds blocking FIAT activity increase osteogenesis
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$497,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biomechanical Testing; Bone; Cell Differentiation; Control Of Gene Expression; Drug Development; Histomorphometry; Metabolic Bone Disease; Mineralization; Osteoblasts; Preclinical Testing
Abstract
There is a need for developing treatments to stimulate bone formation in regenerative medicine since the approved drugs can only be used for a maximum of two years and have potential high risk side effects. We have developed assays that identified two lead compounds (small molecules) for the development of drugs that could stimulate bone formation. We will further characterize the mechanism of action of these compounds and test their safety and efficacy to increase bone mass and strength in preclinical models.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
St-Arnaud, René
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $497,250~ $0~
