Grant: Operating Grant
McMaster University
$631,591.00
Multimerin 1 functions in platelet adhesion and thrombus formation
EF 2013-14
Résumé
Platelets are small blood cells that prevent bleeding. When platelets stick together where blood vessels are diseased, they form blockages that causes heart attacks and strokes. My laboratory is studying a large, "velcro-like" protein in platelets, called multimerin 1, that helps platelet stick. We suspect that multimerin 1 affects the formation of blockages in damaged blood vessels - a process called thrombosis. Multimerin 1 sticks to collagen and von Willebrand factor, which are important to help platelets stick. Multimerin 1 also binds to several proteins involved in blood clotting. This suggests that multimerin 1 affects blockages in blood vessels. The main goals of our project are to test if multimerin 1 is important for thrombosis and for platelets sticking to injured blood vessels.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
291423
Name
Hayward Catherine P
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
Multimerin 1 functions in platelet adhesion and thrombus formation
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$631,591
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Collagen; Factor V; Multimerin 1; Platelet Adhesion; Thrombin Generation; Thrombus Formation; Von Willebrand Factor
Abstract
Platelets are small blood cells that prevent bleeding. When platelets stick together where blood vessels are diseased, they form blockages that causes heart attacks and strokes. My laboratory is studying a large, "velcro-like" protein in platelets, called multimerin 1, that helps platelet stick. We suspect that multimerin 1 affects the formation of blockages in damaged blood vessels - a process called thrombosis. Multimerin 1 sticks to collagen and von Willebrand factor, which are important to help platelets stick. Multimerin 1 also binds to several proteins involved in blood clotting. This suggests that multimerin 1 affects blockages in blood vessels. The main goals of our project are to test if multimerin 1 is important for thrombosis and for platelets sticking to injured blood vessels.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hayward, Catherine P
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $631,591~ $0~
