Grant: Project Grant
University of British Columbia
$910,350.00
Vascular differentiation
EF 2018-19
Résumé
During the development of blood vessels in the embryo some of the blood vessel lining cells, called hemogenic endothelial cells, become blood stem cells, which then create the circulating blood system. However, the majority of the endothelial cells remain as lining cells and help to sculpt the final stable blood vessel system. Little is known about how endothelial cells choose to become blood cells or remain as endothelial cells. Even less is known about how these different kinds of endothelial cells support each other to create properly functioning blood and blood vessel systems.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
401799
Name
Karsan Aly
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - C: Vascular System
Projecttitle
Vascular differentiation
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$910,350
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Endothelial-To-Hematopoietic Transition; Hematopoiesis; Hemogenic Endothelium; Meis 1; Transcription Factors; Vascular Development; Vascular Endothelium
Abstract
During the development of blood vessels in the embryo some of the blood vessel lining cells, called hemogenic endothelial cells, become blood stem cells, which then create the circulating blood system. However, the majority of the endothelial cells remain as lining cells and help to sculpt the final stable blood vessel system. Little is known about how endothelial cells choose to become blood cells or remain as endothelial cells. Even less is known about how these different kinds of endothelial cells support each other to create properly functioning blood and blood vessel systems.
Competitiondate
201903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Karsan, Aly
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $910,350~ $0~
