Grant: Operating Grant
Research Institute of the McGill University Health Centre
$472,289.00
Genetics of high density lipoproteins(HDL)
EF 2008-09
Résumé
Heart attacks often have a genetic or familial basis. We have focused our work of the genetics of a common cardiovascular risk factor, high density lipoproteins (the "good" cholesterol. Taking advantage of large families in the province of Quebec, we have identified a new gene on chromosome 16 that is associated with HDL levels in man. This gene, called WWOX is well known in the cancer field, because it acts as a tumor-suppressing gene. A new role for this gene in the metabolism of cholesterol has recently been found. We will now explore the role of WWOX in HDL and in cardiovascular disease.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
179406
Name
Genest Jacques
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - B: Heart and Circulation
Projecttitle
Genetics of high density lipoproteins(HDL)
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$472,289
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cholesterol; Genetics; High Density Lipoproteins; Lipoproteins
Abstract
Heart attacks often have a genetic or familial basis. We have focused our work of the genetics of a common cardiovascular risk factor, high density lipoproteins (the "good" cholesterol. Taking advantage of large families in the province of Quebec, we have identified a new gene on chromosome 16 that is associated with HDL levels in man. This gene, called WWOX is well known in the cancer field, because it acts as a tumor-suppressing gene. A new role for this gene in the metabolism of cholesterol has recently been found. We will now explore the role of WWOX in HDL and in cardiovascular disease.
Competitiondate
200903
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Genest, Jacques
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $472,289~ $0~
