Grant: Operating Grant

Podocalyxin is a cell surface molecule that contributes to the poor outcome and the metastasis of breast, ovarian, prostate, liver, pancreatic, kidney and colon cancers. We have developed experimental models to investigate how podocalyxin contributes to breast cancer metastasis specifically. We will now use these models to determine which members of a set of podocalyxin function-blocking compounds that we are developing are able to inhibit this metastasis. Therefore, the overarching goal of this project is to identify novel anti-metastatic compounds with the potential to be broadly applicable as therapeutic agents in a wide variety of tumour types.