Grant: Project Grant

Over the last 10-20 years, concerns about how social isolation and loneliness affect people's mental and physical health have been growing. These problems were also exacerbated by the recent COVID-19 pandemic, which unintentionally resulted in increasing loneliness and isolation, particularly among young people (15-24yrs) and the older population (65+yrs). People experiencing social isolation have increased rates of physical and mental health problems, such as cardiovascular disease, depression, anxiety, have a decreased quality of life, and an increased likelihood of death due to any cause. Interestingly, social isolation in both people and in animals cause similar behavioural changes such as reduced sleep, inactivity, and memory problems. Even though social isolation and feelings of loneliness are linked to such negative health outcomes, very little is known about how a lack of social experience changes the brain to cause behavioural and physical changes. Here, we will study the behavioural changes caused by isolation. Using the model organism Drosophila melanogaster, we recently discovered that social isolation reduces the numbers of synapses in their brains by 20-40%, and we find Drosophila exhibit behavioural changes including decreased sleep, reduced activity, and impaired memory, similar to what is seen in people. Through the experiments proposed, we aim to determine how a lack of social experience causes this reduction in synapses, and how it alters information processing in the brain, leading to the behavioural changes we see. Understanding the neurobiological underpinnings of how social interaction alters the nervous system can reveal fundamental properties about our nervous systems and methods to mitigate or reverse the detrimental effects of social isolation in people.