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Grant: Discovery Grants Program - Individual

Toronto Metropolitan University

$64,000.00

Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization

EF 2024-25

Résumé
The need for custom-fit, strong, and long-lasting implants for bone fracture fixation still poses major challenges to researchers and surgeons, as metallic implants fail to optimally transfer the load to the host bone. Despite modern advances in implants' designs and treatment options, complications associated with metal implants remain unresolved. The long term objective of my proposed research program is to develop an innovative manufacturing platform to fabricate the next generation of hybrid composite implants with antimicrobial capabilities and advanced performance. Specifically, my research program aims to achieve the following short term objectives: 1) Create a new, integrated platform that combines a 6DOF robotic arm, a 3D extruder, and a UVC-LED device to systematically 3D print fracture fixation implants with improved properties. 2) Develop an antimicrobial coating technology to improve the natural fibres' wettability and also protect them from mold, bacteria, and other microbial contaminants. 3) Fabricate the hybrid composite implants using the new platform and perform multiscale experimental characterization. 4) Develop a new multiscale, physics-based model to predict the mechanical behaviour and the long term durability of these antimicrobial, 3D-printed composite implants. To achieve these goals, we will design and integrate an innovative UVC-LED device into a 3D printing platform so that the hybrid fibres can be sterilized while they are being fabricated. We will transform a multipurpose robot platform to incorporate a 3D extruder in order to 3D print both natural and synthetic fibres. We will improve the properties of the fibres by using a low cost, non-leaching, and environmentally friendly preservative. We will perform multiscale testing of the 3D-printed hybrid composites to investigate their mechanical behaviour using advanced destructive and non-destructive testing techniques. We will also develop, and validate a new multiscale model to predict their damage and fatigue behaviour.  From an economic and environmental perspective, the proposed research program is vital for Canada's manufacturing industry. It will advance the state-of-the-art manufacturing of fibre-reinforced composites by improving our understanding of the effects of UV-LED sterilization and hybridization on their technical properties, processing, and performance. It will also guide the development of new, high performance, lightweight, and cost effective biocomposite structures. Custom-fit healthcare implants, reduced environmental impact, and cost savings are among the immediate benefits of the proposed technology. Canada will also benefit from the highly skilled HQP who will be trained and supported by this research program. A total of 12 HQPs, including 50% women and 50% men, will be trained in a highly collaborative, equitable, diverse, and inclusive environment in various areas relevant to the natural sciences and engineering (NSE) field.
Programme
Discovery Grants Program - Individual
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data

Tel que publié

Application id
RGPIN-2019-05615
Name nom
Bougherara, Habiba
Department département
Mechanical and Industrial Engineering - Mechanical and Industrial Engineering
Organization id
43
Institution établissement
Toronto Metropolitan University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2019
Award amount
64000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
1512
Committee name en
Mechanical Engineering
Committee name fr
Génie mécanique
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
2107
Research subject group en
Mechanical engineering
Research subject group fr
Génie mécanique
Research subject en
Modelling, simulation and finite element methods
Research subject fr
Modélisation, simulation et méthodes des éléments finis
Field of research list names en
Not available
Field of research list names fr
Non disponible
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization
Keywords
facture fixation implants; antibacterial materials; processing, testing, and characterization; uv-led technology; damage & fatigue; multiscale modeling; numerical simulations; hybrid composites; natural & synthetic fibres; additive manufacturing
Application summary
The need for custom-fit, strong, and long-lasting implants for bone fracture fixation still poses major challenges to researchers and surgeons, as metallic implants fail to optimally transfer the load to the host bone. Despite modern advances in implants' designs and treatment options, complications associated with metal implants remain unresolved. The long term objective of my proposed research program is to develop an innovative manufacturing platform to fabricate the next generation of hybrid composite implants with antimicrobial capabilities and advanced performance. Specifically, my research program aims to achieve the following short term objectives: 1) Create a new, integrated platform that combines a 6DOF robotic arm, a 3D extruder, and a UVC-LED device to systematically 3D print fracture fixation implants with improved properties. 2) Develop an antimicrobial coating technology to improve the natural fibres' wettability and also protect them from mold, bacteria, and other microbial contaminants. 3) Fabricate the hybrid composite implants using the new platform and perform multiscale experimental characterization. 4) Develop a new multiscale, physics-based model to predict the mechanical behaviour and the long term durability of these antimicrobial, 3D-printed composite implants. To achieve these goals, we will design and integrate an innovative UVC-LED device into a 3D printing platform so that the hybrid fibres can be sterilized while they are being fabricated. We will transform a multipurpose robot platform to incorporate a 3D extruder in order to 3D print both natural and synthetic fibres. We will improve the properties of the fibres by using a low cost, non-leaching, and environmentally friendly preservative. We will perform multiscale testing of the 3D-printed hybrid composites to investigate their mechanical behaviour using advanced destructive and non-destructive testing techniques. We will also develop, and validate a new multiscale model to predict their damage and fatigue behaviour.  From an economic and environmental perspective, the proposed research program is vital for Canada's manufacturing industry. It will advance the state-of-the-art manufacturing of fibre-reinforced composites by improving our understanding of the effects of UV-LED sterilization and hybridization on their technical properties, processing, and performance. It will also guide the development of new, high performance, lightweight, and cost effective biocomposite structures. Custom-fit healthcare implants, reduced environmental impact, and cost savings are among the immediate benefits of the proposed technology. Canada will also benefit from the highly skilled HQP who will be trained and supported by this research program. A total of 12 HQPs, including 50% women and 50% men, will be trained in a highly collaborative, equitable, diverse, and inclusive environment in various areas relevant to the natural sciences and engineering (NSE) field.